Pink News: Pomegranate Juice May Help Prevent Breast Cancer Metastasis
Something that can be found in our refridgerator or grocery store can possibly prevent Breast Cancer. Find out what.
In the pink month – the National Breast Cancer Awareness Month, we publish the following to let our readers know that drinking pomegranate juice may not be a bad thing to do when it comes to preventing or treating breast cancer.
A new study published in Integrative Cancer Therapies suggests drinking pomegranate juice may help prevent breast cancer from spreading to other organs.
The study led by Khan G.N. and colleagues from the University of Michigan in Ann Arbor, Michigan shows a pomegranate fruit extract inhibits NF-kb-dependent reporter gene expression, which is linked with proliferation, invasion, and motility in aggressive breast cancer phenotypes.
Pomegranate fruit extract or juice has been found to possess antiproliferative, proapoptotic and anti-inflammatory effects in prostate, lung and other cancers, according to the background information in the study report.
These anticancer properties prompted the researchers to speculate that pomegranate juice or extract may also have a protective effect against breast cancer .
For the study, Khan et al. prepared a pomegranate fruit extract consisting of both fermented juice and seed oil and tested it in aggressive breast cancer cell lines to see if it has an effect on the NF-kb pathway, which is active in the aggressive breast cancer cells.
The pomegranate fruit extract was found to consist of mainly ellagitannins and phenolic acids in the aqueous phase and conjugated octadecatrienoic acids in the lipid phase from the seeds.
The researchers reported “The aqueous PFE dose-dependently inhibited NF-kB-dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression.”
RhoC and RhoA are two related small GTPases involved in mammary gland carcinogenesis.
Khan concluded “Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.”
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